Why remove the thyroid gland in order
to eliminate the symptoms of benign nodules?

ModìLite is ECHOLASER Therapy for treating lesions of the neck, in particular, benign thyroid nodules.

The name of the treatment contains in a single word the application area (the neck, “Modì” was the nickname of Tuscan painter, Amedeo Modigliani, who portrayed female subjects with very long, slim necks) and “Lite”, which on one hand refers to the lightweight and micro-invasiveness of the treatment, and on the other, the therapeutic source (Light, therefore Laser).

The name ModìLite allows for differentiating the procedure performed with ECHOLASER (micro-invasiveness and multi-fibre approach in a single system) from the other thermal ablation techniques.


ModìLite is indicated for those who have one or more benign solid thyroid nodules which are large enough to create aesthetic damage or local compression symptoms, or for those who prefer not to undergo surgery. ModìLite is also a safe and effective treatment for subjects who, due to critical medical conditions, are not able to undergo surgery.
Despite focusing on treatment of benign solid thyroid nodules, Modìlite is also effective for malignant neck lesions such as metastatic lymph nodes. With this application, the treatment is radical, obtaining complete ablation of the lesion.



  • Shrinkage of the thyroid nodule volume with consequent gradual and steady relief from symptoms based on Laser Induced CytoReduction (LICR) process;
  • Complete ablation of malignant neck tumours, with a sufficient safety margin

What is it?

Modìlite consists of the percutaneous insertion of optical fibres (1 or 2 depending on the size of the nodule), and the delivery of laser energy for several minutes which causes the heating of the tissues until they are destroyed. Subsequently, the progressive reduction of the volume of the thyroid nodule (reduction of at least > 50% compared to the basal volume at the one-year follow-up) induced by the natural reduction mechanisms of the necrotic tissues of the human body leads to the disappearance of the compressive symptoms and aesthetic damage to the neck. The planning of the treatment, the insertion of the needles and the monitoring are all carried out under ultrasound guidance. In order to facilitate the insertion manoeuvre and plan the best positioning of the needles in the lesion, ECHOLASER exploits:

  • dedicated multi-applicator Guiding Systems for ultrasound probes specifically designed for the anatomical area of the thyroid, with the relative Biopsy Software that displays the guidelines on the screen;
  • Planning Software in the ultrasound unit that allows for choosing among the various treatment possibilities, the most suitable and safest for each specific case, and for controlling the correct positioning of the needles inside the nodule.

A single ModìLite treatment gives rise to a significant and persistent reduction in the volume of the thyroid nodule and improves the local symptoms without any changes to the thyroid function.

1./2. LA332 Esaote probe with dedicated multi-fibre Guiding System
3. Biopsy Software related to multi-fibre Guiding System / 4.Planning Software


  • a reduction in the compressive symptoms and/or aesthetic damage
  • “in situ” thermal destruction with a consequent reduction of the nodule volume
  • preservation of the healthy tissue and the organ function
  • highly predictable and repeatable coagulation volume, as required in the small organs
  • use of fine, a-traumatic needles for the neck structures
  • possibility of treating patients with pace-makers (excellent electromagnetic compatibility)
  • absence of general anaesthesia (thanks to the very fine needles not even local anaesthetic is necessary)
  • short duration of the treatment (few minutes)
  • absence of scars on the neck
  • rapid recovery times
  • life-long hormone replacement therapy not necessary
  • no or insignificant post-treatment pain

For more details about the ModìLite procedure, EchoLaser Therapy on benign thyroid nodules, please visit the website:




Clinical Case no.1

Benign Thyroid Nodule

A patient with a solid isoechoic nodule (volume 20ml) in the right thyroid lobe, underwent EchoLaser Therapy. A patient with a solid isoechoic nodule (volume 20ml) in the right thyroid lobe, underwent Laser Thermotherapy. During the treatment no discomfort was reported by the patient.

CEUS image after the treatment showing the hypoechoic zone of the coagulation area


The ultrasound scan at the two-year follow-up showed a reduction in the nodule volume equal to 70% compared to the basal volume.

US images before the treatment and two-year follow-up showing the reduction of the nodule

Images by courtesy of Dr. Rago (Cisanello Hospital, Pisa)

Clinical Case no.2

Metastatic Lymph nodes in the neck

Patient with metastatic lymph node from papillary thyroid carcinoma has been treated with EchoLaser Therapy with two fibres.

CEUS image showing the high absorption of the contrast of the pathological lymph node

US image showing two fibres inside the lymph node


CEUS image showing the absence of enhancement after the treatment


Images by courtesy of Dr. Giovanni Mauri (IEO Hospital, Milan)



Benign Thyroid Nodule

Quality of life and outcomes in patients with a large toxic adenoma undergoing laser ablation plus radioiodine vs lobectomy.
Negro R, Greco G.
Int J Hyperthermia. 2018 Dec 16:1-5.

Benign thyroid nodule unresponsive to radiofrequency ablation treated with laser ablation: a case report.
Oddo S, Balestra M, Vera L, Giusti M.
J Med Case Rep. 2018 May 11;12(1):127.

Percutaneous Ethanol Injection in Combination with Laser Ablation for a 100 ml Partially Cystic Thyroid Nodule.
Negro R, Greco G.
Case Rep Endocrinol. 2018 Feb 15;2018:8046378.

A single session of laser ablation for toxic thyroid nodules: three-year follow-up results.
Gambelunghe G, Stefanetti E, Colella R, Monacelli M, Avenia N, De Feo P.
Int J Hyperthermia. 2018 Feb 22:1-5.

Quality of Life in Patients Treated with Percutaneous Laser Ablation for Non-Functioning Benign Thyroid Nodules: A Prospective Single-Center Study
Oddo S, Felix E, Mussap M, Giusti M.
Korean J Radiol 2018;19(1):175-184

Image-guided thermal ablation of benign thyroid nodules.
Pacella CM.
J Ultrasound. 2017 Nov 14;20(4):347-349.

A comparison of laser with radiofrequency ablation for the treatment of benign thyroid nodules: a propensity score matching analysis.
Pacella CM et al
Int J Hyperthermia. 2017 Jun 12:1-9.

Percutaneous laser ablation for benign thyroid nodules: a meta-analysis.
Sui WF, Li JY, Fu JH.
Oncotarget. 2017 May 17.

Laser ablation is more effective for spongiform than solid thyroid nodules. A 4-year retrospective follow-up study.
Negro R, Salemb TM and Greco G.
Int J Hyperthermia. 2016 Nov;32(7):822-8.

Benign thyroid nodules treatment using percutaneous laser ablation (PLA) and radiofrequency ablation (RFA).
Mauri G, Cova L, Monaco CG, Sconfienza LM, Corbetta S, Benedini S, Ambrogi F, Milani V, Baroli A, Ierace T& Solbiati L
Int J Hyperthermia. 2016 Nov 15:1-5.

Detection of the Single-Session Complete Ablation Rate by Contrast-Enhanced Ultrasound during Ultrasound-Guided Laser Ablation for Benign Thyroid Nodules: A Prospective Study
Shuhua Ma, Ping Zhou, XiaominWu, Shuangming Tian, and Yongfeng Zhao
BioMed Research International Volume 2016 (2016), Article ID 9565364, 8 pages

AACE/AME/ETA Thyroid Nodule Guidelines
Gharib H, Papini E, Garber JR, Duick DS, Harrel RM, Hegedüs L, Paschke R, Valcavi R, Vitti P
Endocr Pract. 2016;22 (Suppl 1)

Thyroid: Laser ablation of thyroid nodules is rapid, safe and effective
Geach T.
Nat Rev Endocrinol. 2015 Nov;11(11):631.

Outcomes and Risk Factors for Complications of Laser Ablation for Thyroid Nodules. A Multicenter Study on 1531 Patients.
Pacella CM, Mauri G, Achille G, Barbaro D, Bizzarri G, De Feo P, Di Stasio E, Esposito R, Gambelunghe G, Misischi I, Raggiunti B, Rago T, Patelli GL, D’Este S, Vitti P, Papini E.
J Clin Endocrinol Metab. 2015 Oct;100(10):3903-10.

Ultrasound-guided percutaneous laser ablation (LA) in treating symptomatic solid benign thyroid nodules: Our experience in 45 patients.
Achille G, Zizzi S, Di Stasio E, Grammatica A, Grammatica L.
Head Neck. 2014 Dec 18.

Thyroid nodule morphology affects the efficacy of ultrasound-guided interstitial laser ablation: A nested case-control study.
Gambelunghe G, Bini V, Stefanetti E, Colella R, Monacelli M, Avenia N, De Feo P.
Int J Hyperthermia. 2014 Oct 7:1-4

Long-term Efficacy of Ultrasound-Guided Laser Ablation for Benign Solid Thyroid Nodules. Results of a Three-Year Multicenter Prospective Randomized Trial.
Papini E, Rago T, Gambelunghe G, Valcavi R, Bizzarri G, Vitti P, De Feo P, Riganti F, Misischi I, Di Stasio E, Pacella CM.
J Clin Endocrinol Metab. 2014 Oct;99(10)

Laser ablation and 131-iodine: a 24-month pilot study of combined treatment for large toxic nodular goiter.
Chianelli M, Bizzarri G, Todino V, Misischi I, Bianchini A, Graziano F, Guglielmi R, Pacella CM, Gharib H, Papini E.
J Clin Endocrinol Metab. 2014 Jul;99(7)

Diagnosis of endocrine disease: thyroid ultrasound (US) and US-assisted procedures: from the shadows into an array of applications.
Papini E, Pacella CM, Hegedus L.
Eur J Endocrinol. 2014 Mar 14;170(4):R133-46

Clinical review: Nonsurgical, image-guided, minimally invasive therapy for thyroid nodules.
Gharib H, Hegedüs L, Pacella CM, Baek JH, Papini E
J Clin Endocrinol Metab. 2013 Oct;98(10):3949-57.

Image-guided percutaneous ablation therapies for local recurrences of thyroid nodule.
Pacella CM and Papini E
J.Endocrinol.Invest.36: 61-70;2013

The administration of anesthetic in the thyroid pericapsular region increases the possibility of side effects during percutaneous laser photocoagulation of thyroid nodules.
Gambelunghe G, Bini V, Monacelli M, Avenia N, D’Ajello M, Colella R, De Feo P
Lasers Surg Med. 2013

Ultrasound-Guided Interstitial Laser Ablation for Thyroid Nodules Is Effective Only at High Total Amounts of Energy: Results From a Three-Year Pilot Study.
Gambelunghe G, Fede R, Bini V, Monacelli M, Avenia N, D’Ajello M, Colella R, Nasini G, De Feo P
Surg Innov. 2012

Percutaneous Laser Ablation of Cold Benign Thyroid Nodules: A 3-Year Follow-Up Study in 122 Patients.
Valcavi R,Riganti F,Bertani A,Formisano D, Pacella CM
Thyroid 2010; Volume 20, Number 11

Laser and Radiofrequency Ablation procedures.
Valcavi R, Bertani A, Pesenti , Al Jandali, Frasoldati, Formisano, Pacella CM.
Thyroid Ultrasound and Ultrasound-Guided FNA

Treatment of Benign Cold Thyroid Nodules: A Randomized Clinical Trial of Percutaneous Laser Ablation Versus Levothyroxine Therapy or Follow-up
Papini E, Guglielmi R, Bizzarri G, Graziano F, Bianchini A, Brufani C, Pacella S, Valle D, Pacella CM.
Thyroid. 2007 Mar;17(3):229-35.

Thyroid Tissue: US-guided Percutaneous Interstitial Laser Ablation—A Feasibility Study.
Pacella CM, Bizzarri G, Guglielmi R, Anelli V, Bianchini A, Crescenzi A, Pacella S, Papini E.
Radiology. 2000 Dec;217(3):673-7

Metastatic Lymph Node in the neck

Percutaneous ultrasound-guided laser ablation for the treatment of cervical tuberculous lymphadenitis: a pilot study.
Yang G, Fang J, Yu T, Zhang Y, Zhang W, Zhao D, Xu J, Wang C.
J Int Med Res. 2019 Jan 11:300060518821818.

Ultrasound-guided laser ablation for local control of neck recurrences of medullary thyroid cancer. A feasibility study.
Persichetti A, Bizzarri G, Guglielmi R, Barnabei A, Bianchini A, Coccaro C, Appetecchia M, Papini E.
Int J Hyperthermia. 2018 Sep 11:1-5.
Role of ultrasound in the assessment of percutaneous laser ablation of cervical metastatic lymph nodes from thyroid carcinoma.
Zhang L, Zhou W, Zhan W.
Acta Radiol. 2017 Jan 1:284185117721261.

Percutaneous laser ablation for treatment of locally recurrent papillary thyroid carcinoma <15 mm
Zhou W, Zhang L, Zhan W, Jiang S, Zhu Y, Xu S.
Clin Radiol 2016 Dec;71(12):1233-1239.

Treatment of Metastatic Lymph Nodes in the Neck from Papillary Thyroid Carcinoma with Percutaneous Laser Ablation.
Mauri G, Cova L, Ierace T, Baroli A, Di Mauro E, Pacella CM, Goldberg SN, Solbiati L
Cardiovasc Intervent Radiol. 2016 Jul;39(7):1023-30

Percutaneous Laser Ablation of Metastatic Lymph Nodes in the Neck from Papillary thyroid carcinoma: preliminary results.
Mauri G, Cova L, Tondolo T, Ierace T, Baroli A, Di Mauro E, Pacella CM, Goldberg SN, Solbiati L
J Clin Endocrinol Metab. 2013 May 10.

Percutaneous ultrasound-guided laser ablation is effective for treating selected nodal metastases in papillary thyroid cancer.
Papini E, Bizzarri G, Bianchini A, Valle D, Misischi I, Guglielmi R, Salvatori M, Solbiati L, Crescenzi A, Pacella CM, Gharib H.
J Clin Endocrin Metab, 2013 Jan;98(1):E92-7







Videos in the page are commented by the respective health care professionals, expert phisicians in thyroid nodules EchoLaser Therapy.

Professor Bruno Raggiunti
Director of Endocrinology Department, San Liberatore Hospital (Atri) – Italy


Teresa Rago, MD
Assistant Professor of Endocrinology Department, Cisanello Hospital (Pisa) – Italy






Multicentric Randomized Controlled Study of Percutaneous Laser Ablation Versus Follow Up in Benign Thyroid Nodules. Long Term Results

Multicentre Randomized Clinical Trial
No. of patients enrolled: 200
Reference Study Centres: 4, Azienda Ospedaliero-Universitaria di Pisa – Presidio di Cisanello, Ospedale Regina Apostolorum, Azienda Ospedaliera di Perugia, Arcispedale Santa Maria Nuova
Study status: Completed
Registered on
Publications of the results: Long-term Efficacy of Ultrasound-Guided Laser Ablation for Benign Solid Thyroid Nodules. Results of a Three-Year Multicenter Prospective Randomized Trial, Papini E, Rago T, Gambelunghe G, Valcavi R, Bizzarri G, Vitti P, De Feo P, Riganti F, Misischi I, Di Stasio E, Pacella CM. J Clin Endocrinol Metab. 2014 Oct

Laser Ablation Versus Radiofrequency Ablation for Thyroid Nodules (LARA)

Randomised Clinical Trial
No. of patients enrolled: 60
Reference Study Centre: Ospedale, Santa Maria Goretti, Latina
Study status: enrolment of patient
Registered on


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